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Homogenized Bacterial Cellulose Incorporated Polydopamine Sponges for Rapid Hemostasis in Traumatic Wounds
Kamlesh1, Kaushal Shakya1, Vivek Verma1,2,3,4
1Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India.
Biopolymers
|November 22, 2025
Summary
New bacterial cellulose sponges coated with polydopamine nanospheres show excellent hemostatic ability. These biocompatible BC-PDA sponges offer rapid blood clotting, making them promising for surgical and trauma wound management.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Medical Devices
Background:
- Traditional wound dressings lack hemostatic properties.
- Effective bleeding control is critical in surgical and trauma care.
- Need for advanced hemostatic materials.
Purpose of the Study:
- To develop a novel hemostatic dressing using bacterial cellulose (BC) and polydopamine (PDA).
- To evaluate the hemostatic efficacy, stability, and biocompatibility of BC-PDA sponges.
- To understand the mechanism of enhanced blood clotting.
Main Methods:
- Fabrication of bacterial cellulose sponges.
- Coating BC sponges with polydopamine nanospheres via in-situ oxidative polymerization.
- In vitro assessment of fluid absorption, stability, hemostatic ability, and cell biocompatibility.
Main Results:
- BC-PDA sponges demonstrated rapid fluid absorption and robust stability.
- Achieved up to 90% blood clotting efficacy within 90 seconds.
- Showcased excellent antioxidant properties and biocompatibility with mammalian cells.
- PDA's amine groups were identified as key for activating intrinsic coagulation pathways.
Conclusions:
- Successfully fabricated BC/PDA hemostatic sponges with superior properties.
- These sponges present a promising, safe, and effective material for clinical hemostasis.
- The study highlights a sustainable approach for developing advanced wound care solutions.
