Related Experiment Video

Updated: Jan 10, 2026

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
08:29

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

7.6K

SUMOylation and NEDDylation in kidney diseases

Zi-Han Chen1, Dan Li2, Jian-Yu Zhang1

  • 1School of Life Science, Northwest University, Xi'an, Shaanxi, China.

Experimental and Molecular Pathology
|November 22, 2025
PubMed

Insights

Post-translational modifications, SUMOylation and NEDDylation, show promise as therapeutic targets for kidney disease. Modulating these processes may offer new treatments for conditions like renal ischemia-reperfusion injury and diabetic kidney disease.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nephrology

Background:

  • Kidney disease lacks specific treatments due to limited therapeutic targets.
  • Post-translational modifications (PTMs), including SUMOylation and NEDDylation, are emerging as key regulators in kidney function.
  • These ubiquitin-like modifications influence various cellular processes relevant to kidney health.

Purpose of the Study:

  • To explore the role of SUMOylation and NEDDylation as potential therapeutic targets for kidney diseases.
  • To investigate how these PTMs impact different kidney conditions, such as renal ischemia-reperfusion injury and diabetic kidney disease (DKD).
  • To assess the therapeutic potential of activators and inhibitors targeting SUMOylation and NEDDylation pathways.

Main Methods:

  • Review and analysis of existing studies on SUMOylation and NEDDylation in kidney disease models.
  • Examination of the effects of modulating specific SUMOylation and NEDDylation targets (e.g., LKB1, HIF-1α, IKKγ, STAT1, RBMX, Notch1, RhoA) on kidney pathology.
  • Evaluation of the efficacy of known SUMOylation and NEDDylation modulators (e.g., TAK-981, MLN4924).

Main Results:

  • SUMOylation and NEDDylation regulate critical pathways in renal ischemia-reperfusion injury and DKD.
  • Specific modifications, like LKB1 SUMOylation and HIF-1α deSUMOylation, influence renal fibrosis, apoptosis, and oxidative stress.
  • In DKD, modulating SUMOylation (IKKγ, STAT1, RBMX, Notch1) and NEDDylation (RhoA) can attenuate inflammation, fibrosis, and cell injury.
  • Activators and inhibitors of these PTMs demonstrate therapeutic effects in preclinical studies.

Conclusions:

  • SUMOylation and NEDDylation are crucial in the pathogenesis and progression of kidney diseases.
  • Targeting these PTMs offers a promising therapeutic strategy for various kidney disorders.
  • Activators and inhibitors of SUMOylation and NEDDylation represent novel therapeutic candidates for kidney disease treatment.
Keywords:
Diabetic kidney diseaseMLN4924NEDDylationRenal ischemia-reperfusion injurySUMOylationTAK-981

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

586
In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity09:45

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

9.7K

Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.3K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
476
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
184
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
8.6K
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
53.6K
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
271