Related Experiment Video

Updated: May 6, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K

Evaluating the G-ROP criteria sensitivity for type 1 ROP in a North American cohort

Omi Pang1, Nabiha Habib1, Julie Conley2

  • 1Michigan State University College of Human Medicine, East Lansing, Michigan.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|November 22, 2025
PubMed

Insights

The new G-ROP criteria for retinopathy of prematurity (ROP) screening show high sensitivity but missed one case. Further research into twin-to-twin transfusion syndrome is recommended for ROP screening improvements.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Pediatric Medicine

Background:

  • Current retinopathy of prematurity (ROP) screening follows American Academy of Pediatrics (AAP) guidelines.
  • The G-ROP study proposed new criteria with 100% sensitivity for type 1 ROP and a 30% reduction in examinations.
  • Validation of G-ROP criteria in a diverse clinical setting is essential.

Purpose of the Study:

  • To validate the G-ROP screening criteria for retinopathy of prematurity (ROP).
  • To assess the sensitivity and specificity of G-ROP criteria in a midsized Midwestern children's hospital.

Main Methods:

  • Retrospective cohort study of infants screened for ROP (January 2018 - December 2022).
  • Application of G-ROP criteria to infants screened under AAP guidelines.
  • Evaluation of G-ROP sensitivity and specificity for detecting type 1 ROP requiring treatment.

Main Results:

  • 687 infants included; average gestational age 28 weeks, birthweight 1022.5g.
  • 448 infants (65.2%) met G-ROP criteria.
  • G-ROP sensitivity was 97.1% for type 1 ROP, missing one infant requiring treatment.

Conclusions:

  • G-ROP criteria demonstrated high sensitivity but not 100% as in prior studies.
  • The missed case had a history of twin-to-twin transfusion syndrome.
  • Physiologic factors of twin-to-twin transfusion syndrome warrant further investigation for ROP screening optimization.
Abstract

More Related Videos

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

4.1K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.5K

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
631
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.9K
Receiver Operating Characteristic Plot01:15

Receiver Operating Characteristic Plot

A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
586
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.5K
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
1.7K