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Vitreous Hemorrhage Induced by a Persistent Hyaloid Artery
Henry Zou1, Kimberly Drenser2, Brooke Geddie3
1Department of Undergraduate Medical Education, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA, msu.edu.
Case Reports in Ophthalmological Medicine
|April 27, 2026
Summary
Persistent hyaloid artery (PHA) can cause vitreous hemorrhage in infants. This case shows PHA traction leading to hemorrhage after retinopathy of prematurity treatment, emphasizing careful management.
Area of Science:
- Ophthalmology
- Neonatal Care
- Vascular Biology
Background:
- The hyaloid artery is a fetal vascular system; its persistence (PHA) can cause serious eye complications.
- Complications of PHA include amblyopia, cataracts, glaucoma, vitreous hemorrhage, and retinal detachment.
- Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
Purpose of the Study:
- To report a case of vitreous hemorrhage secondary to PHA traction in an infant treated for ROP.
- To highlight the importance of considering PHA in ROP management.
Main Methods:
- Case report of a premature infant with threshold ROP.
- Treatment involved laser photocoagulation for ROP.
- Management of subsequent vitreous hemorrhage via vitrectomy.
Main Results:
- The infant developed vitreous hemorrhage attributed to PHA traction post-ROP treatment.
- The patient required vitrectomy for the hemorrhage.
- Long-term complications included anisometropic myopia and amblyopia.
Conclusions:
- Vitreous hemorrhage is a rare but severe complication of PHA.
- This case underscores the need to consider PHA in ROP management to prevent complications.
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