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Nervous Tissue: Glial Cells01:31

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Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
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Glioneuronal Tumors.

Alok Jaju1, Kristen W Yeom2

  • 1Department of Radiology, Phoenix Children's Hospital, Phoenix, AZ, USA; Department of Child Health and Radiology, University of Arizona College of Medicine, AZ, USA; Department of Radiology, Creighton University School of Medicine, AZ, USA.

Neuroimaging Clinics of North America
|November 22, 2025
PubMed
Summary
This summary is machine-generated.

Glioneuronal tumors, rare brain neoplasms in young people, require precise diagnosis using advanced neuroimaging. This review highlights MRI

Keywords:
DGONCDLGNTDNETGangliogliomaGlioneuronal tumorsLow-grade epilepsy-associated tumorsNeuronal tumorsPediatric low-grade tumors

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Area of Science:

  • Neuro-oncology
  • Radiology
  • Pathology

Background:

  • Glioneuronal tumors are rare central nervous system neoplasms with mixed neuronal and glial elements.
  • These tumors predominantly affect pediatric and young adult populations.
  • Accurate diagnosis and management are crucial due to their complex nature.

Purpose of the Study:

  • To provide an in-depth analysis of glioneuronal tumors.
  • To emphasize the critical role of neuroimaging in diagnosis, differential diagnosis, and surgical planning.
  • To synthesize current knowledge and discuss future directions in the management of these tumors.

Main Methods:

  • Review of current literature on glioneuronal tumors.
  • Emphasis on Magnetic Resonance (MR) imaging findings.
  • Inclusion of advanced imaging techniques like perfusion and functional MR imaging.
  • Discussion of radiomics, molecular profiling, and personalized medicine.

Main Results:

  • MR imaging is the cornerstone for diagnosing glioneuronal tumors.
  • Advanced MR techniques offer additional diagnostic insights.
  • Prognosis varies, generally favorable for low-grade tumors but challenging for high-grade variants.
  • Radiomics and molecular profiling are emerging as key tools for personalized management.

Conclusions:

  • Neuroimaging, particularly MR imaging, plays a pivotal role in the diagnosis and management of glioneuronal tumors.
  • Innovations in radiomics and molecular profiling are transforming treatment strategies.
  • Continued research and technological advancements promise improved outcomes for patients with glioneuronal tumors.