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Using Controlled Drug Delivery Systems to Increase the Effectiveness of Intratumoral Immuno-oncology
Shonit Nair Sharma1, Rui Dai2, Feodor Morozov3
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Dermatology, Harvard Medical School, Boston, Massachusetts.
None:
Immunotherapy against solid tumors remains limited in part by challenges in predictable and sustained intratumoral delivery. Controlled drug delivery systems, such as hydrogels, nanoparticles, and medical devices, may address these challenges by offering tunable loading capacities and release profiles for targeted solid tumors. In this review, we highlight successful and ongoing implementations of controlled drug delivery systems that have demonstrated potential to sustain antitumoral immune activation while mitigating systemic toxicity. Together, we review the promise of combined advances in biomaterials, nanotechnology, and bioengineering for improving clinical efficacy of cancer immunotherapies.
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