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Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Pulmonary Angiogram
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Updated: Jun 25, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Published on: May 8, 2018

Advances in Radioembolization for Liver Cancer.

Sam Meiselman¹, M Allan Thomas², J Daniel Giardina²

¹Washington University in St. Louis School of Medicine, St. Louis, Missouri.

Journal of Vascular and Interventional Radiology : JVIR

|November 23, 2025

Summary

This summary is machine-generated.

Radioembolization using yttrium-90 microspheres is effective for liver cancer. Preclinical research explores image-guided delivery of novel agents and radionuclides to overcome current limitations and enhance cancer treatment.

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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Area of Science:

Oncology
Radiology
Biomedical Engineering

Background:

Radioembolization, particularly with yttrium-90 microspheres, is a well-established treatment for primary and metastatic liver cancers.
Advancements in patient selection and dosimetry have improved its efficacy, establishing it as a frontline therapy in various clinical settings.
Current limitations hinder the full potential of radioembolization for liver cancers and other solid tumors.

Purpose of the Study:

To review preclinical advances in image-guided delivery of cancer therapeutics aimed at enhancing radioembolization.
To explore novel strategies including codelivery of agents and alternative radionuclides for improved cancer treatment.

Main Methods:

Review of preclinical research on image-guided delivery systems for cancer therapeutics.
Investigation of codelivery strategies involving nanophotosensitizers, chemotherapeutics, immune adjuvants, and photothermal agents.
Exploration of alternative radionuclides, such as alpha emitters, for local delivery via image guidance.

Main Results:

Preclinical studies demonstrate potential for image-guided delivery of novel agents to improve radioembolization.
Codelivery of various therapeutic agents shows promise in harnessing additional tumoricidal mechanisms.
Alternative radionuclides offer new possibilities for targeted radionuclide therapy.

Conclusions:

Preclinical advances in image-guided delivery and novel agents are poised to expand the applications of radioembolization.
Future research focusing on these innovative approaches may overcome existing limitations in liver cancer and solid tumor treatment.
Image-guided delivery of radionuclides and combination therapies represent a promising frontier in cancer therapeutics.