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Association between bone turnover markers and alveolar socket healing rate: A cross-sectional study
Ryutaro Nakagaki1, Yusuke Kondo2, Kiyoshi Shimada1
1Division of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Oral and Maxillofacial Surgery
|November 23, 2025
Summary
Bone turnover markers like P1NP and NTx correlate with early alveolar socket healing after tooth extraction. High bone turnover may indicate faster healing rates in the initial post-extraction period, potentially aiding implant treatment planning.
Area of Science:
- Oral surgery and implantology
- Biomarkers and bone metabolism
Background:
- Alveolar socket healing is crucial for successful dental implant placement.
- Understanding bone turnover markers (BTMs) can provide insights into healing dynamics.
Purpose of the Study:
- To investigate the relationship between BTMs and alveolar socket healing rates.
- To assess the potential application of BTMs in predicting implant treatment outcomes.
Main Methods:
- 21 patients undergoing molar extractions for implant treatment were studied.
- Alveolar bone density was measured using an AI system at 0, 2, and 6 months post-extraction.
- Key BTMs including P1NP, BAP, NTx, and TRACP-5b were quantified.
Main Results:
- Overall 6-month healing rate showed no significant correlation with all BTMs.
- Procollagen type I N-terminal propeptide (P1NP) and collagen cross-linked N-telopeptide (NTx) demonstrated a significant positive association with healing in the first 2 months.
- Tartrate-resistant acid phosphatase 5b (TRACP-5b) showed a positive association tendency during the initial 2 months.
Conclusions:
- Bone formation (P1NP) and resorption (NTx, TRACP-5b) markers are linked to early alveolar socket healing.
- Individuals with higher bone turnover may experience accelerated early healing post-extraction.
- These findings suggest BTMs could inform early stages of implant treatment planning.
