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Updated: Jul 29, 2026

Microfabricated Platforms for Mechanically Dynamic Cell Culture
Published on: December 26, 2010
Inverse design of periodic microstructures with targeted nonlinear mechanical behaviour
Dilaksan Thillaithevan1, Ryan Murphy1, Robert Hewson1
1Department of Aeronautics, Imperial College London, London, UK.
None:
This paper introduces an inverse design framework for the precise tailoring of desired nonlinear mechanical responses in periodic microstructures, with particular focus on prescribed nonlinear stress-strain relationships. The topology optimization hinges on minimizing the error between the target and realized properties of the microstructures. A deformation-driven homogenization framework is setup. The periodic constraints needed for the microscale equilibrium equation are imposed through strongly enforced periodic boundary conditions and the removal of the translational nullspace, avoiding the need for Lagrange multipliers, greatly simplifying the implementation. Automatic differentiation is leveraged to efficiently calculate the necessary sensitivities for the gradient-based optimization. To further aid the design of discrete designs a intermediate density penalty constraint is proposed. Numerical examples underscore the efficacy of our methodology, showcasing microstructures that demonstrate targeted softening and stiffening as well as distinctive directional behaviour.
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