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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
214
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

180
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
180
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

223
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

186
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
186
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

212
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
212
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Related Experiment Video

Updated: Jan 10, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

655

Nexobrid Use in the Elderly.

Alexander Lugilde Guerbek1, Jordi Serracanta Domenech1, Antonio Bulla1

  • 1Vall d'Hebron Burns Unit, Plastic Surgery Department, 08035 Barcelona, Spain.

European Burn Journal
|November 24, 2025
PubMed
Summary
This summary is machine-generated.

Enzymatic debridement with Nexobrid (NXB) safely removes eschar in elderly burn patients, preventing compartment syndrome. While grafting is often still needed, NXB optimizes wound beds for better outcomes in this high-risk group.

Keywords:
Nexobridelderlyexperience

Related Experiment Videos

Last Updated: Jan 10, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

655

Area of Science:

  • Burn Care
  • Geriatric Medicine
  • Wound Healing

Background:

  • Enzymatic debridement using Nexobrid (NXB) is a recognized burn care treatment.
  • Outcomes of NXB in elderly patients (≥65 years) are not well-documented.
  • This study assesses NXB's safety and efficacy in this specific demographic.

Purpose of the Study:

  • To evaluate the safety and efficacy of Nexobrid (NXB) for enzymatic debridement in elderly burn patients (≥65 years).
  • To characterize clinical outcomes, including complications and healing times, associated with NXB treatment in this population.

Main Methods:

  • Retrospective case-series analysis of 43 elderly patients (mean age 74.5 years) with deep partial- to full-thickness burns.
  • Data collected included demographics, burn characteristics, NXB treatment details, and complications.
  • Analysis focused on debrided area, need for escharotomy, grafting requirements, mortality, and scarring.

Main Results:

  • NXB was applied to a mean of 7.41% TBSA, primarily on limbs and hands.
  • No escharotomies were required in NXB-treated areas; 76.7% of patients ultimately needed surgical autografting.
  • Mortality was 25.6%, lower than expected for a median revised Baux score of 90. Hypertrophic scarring occurred in 28.1% of survivors, with a median healing time of 63 days.

Conclusions:

  • Nexobrid (NXB) demonstrates a strong safety profile in elderly burn patients, effectively removing eschar and preventing compartment syndrome.
  • The primary benefit in this age group is optimizing the wound bed for grafting rather than reducing surgical intervention.
  • While NXB is beneficial, age-related delayed healing means subsequent grafting is frequently necessary.