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Updated: Jan 10, 2026

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Microlasers Integrated with Microfluidic Droplets for Exosome Profiling at the Single-Cell Level.

Tian Zhou¹, Guocheng Fang^1,2, Ningyuan Nie¹

¹School of Electrical and Electronics Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.

Analytical Chemistry

|November 24, 2025

Summary

This summary is machine-generated.

We developed a highly sensitive whispering-gallery-mode (WGM) microlaser platform for analyzing single-cell exosomes. This technology enables real-time monitoring of exosome secretion, advancing cellular communication research.

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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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Published on: October 15, 2013

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Last Updated: Jan 10, 2026

Fluorescence detection methods for microfluidic droplet platforms

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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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Published on: May 24, 2019

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Area of Science:

Biotechnology
Nanotechnology
Cell Biology

Background:

Single-cell exosome analysis is crucial for understanding cellular heterogeneity and intercellular communication.
Conventional methods lack sensitivity and are susceptible to interference from biological fluids.

Purpose of the Study:

To introduce whispering-gallery-mode (WGM) microlasers for highly sensitive, single-cell exosome analysis.
To enable real-time, long-term monitoring of exosome secretion from individual cells.

Main Methods:

Coencapsulation of individual cells with WGM microlasers in microfluidic droplets.
Integration of fluorescence resonance energy transfer (FRET) with laser emission for signal amplification.
High-throughput generation of uniform microlasers using droplet microfluidics.

Main Results:

Achieved ultrahigh detection sensitivity for exosome analysis.
Demonstrated real-time and long-term monitoring capabilities.
Enabled consistent performance through uniform microlaser generation.

Conclusions:

WGM microlasers provide a powerful platform for sensitive single-cell exosome analysis.
This approach enhances biomolecular assays and has broad biomedical application potential.
The technology promises advancements in diagnostics, therapeutics, and cellular profiling.