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Updated: Jan 10, 2026

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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
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DSSCC net enhanced skin cancer classification using SMOTE Tomek and optimized convolutional neural network
Muhammad Aqib Javaid1, Muhammad Suleman Shahzad2, Hafiz Muhammad Faisal Shehzad1
1Department of Software Engineering, University of Sargodha, Sargodha, Pakistan.
Scientific Reports
|November 25, 2025
Summary
This study introduces DSSCC-Net, a deep learning model that accurately classifies skin cancer using dermoscopic images. It effectively handles data imbalance, achieving high accuracy for early detection and clinical use.
Area of Science:
- Dermatology
- Artificial Intelligence
- Medical Imaging
Background:
- Skin cancer diagnosis relies on expert evaluation, which can be error-prone.
- Current deep learning models struggle with imbalanced datasets, hindering accurate classification of rare skin lesions.
- There is a need for robust, efficient, and interpretable AI models for early skin cancer detection.
Purpose of the Study:
- To develop and evaluate DSSCC-Net, a novel deep learning framework for accurate skin cancer classification.
- To address the challenge of class imbalance in dermoscopic datasets using SMOTE-Tomek oversampling.
- To enhance the interpretability of the classification model for clinical application.
Main Methods:
- Developed DSSCC-Net, a deep convolutional neural network (CNN) integrated with SMOTE-Tomek oversampling.
- Trained and validated the model on diverse dermoscopic datasets (HAM10000, ISIC 2018, PH2).
- Utilized data augmentation, dropout layers, ReLU activation, and Grad-CAM for model optimization and interpretability.
Main Results:
- DSSCC-Net achieved high classification accuracy (average 97.82% ± 0.37%) and AUC (99.43%).
- The model demonstrated superior performance compared to existing state-of-the-art models like VGG-16 and ResNet-152.
- SMOTE-Tomek integration significantly improved minority-class detection, with balanced precision (97%) and recall (97%).
Conclusions:
- DSSCC-Net offers a robust and interpretable solution for skin cancer classification, outperforming current methods.
- The model's ability to handle class imbalance makes it suitable for real-world clinical deployment.
- DSSCC-Net sets a new benchmark, paving the way for AI-assisted early skin cancer diagnosis.
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