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Related Concept Videos

Open and closed-loop control systems01:17

Open and closed-loop control systems

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Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
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Physiological Control of Respiration01:23

Physiological Control of Respiration

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Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
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Positive and Negative Feedback Loops01:18

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Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
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Physiology of Respiration II: Neurogenic Control of Respiration01:22

Physiology of Respiration II: Neurogenic Control of Respiration

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The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
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Neural Control of Respiration01:18

Neural Control of Respiration

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The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
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Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

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Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
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Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
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Physiological closed-loop control in critical care: opportunities for innovations.

Jin-Oh Hahn1, Omer T Inan2

  • 1University of Maryland, College Park, MD, United States of America.

Progress in Biomedical Engineering (Bristol, England)
|November 25, 2025
PubMed
Summary

Physiological closed-loop control (PCLC) systems offer advanced medical automation. Addressing limitations in current PCLC design and assessment is crucial for enhancing patient care and safety in critical settings.

Area of Science:

  • Biomedical Engineering
  • Control Systems
  • Medical Informatics

Background:

Keywords:
critical caremedical automationphysiological closed-loop controlphysiological monitoring

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  • Physiological closed-loop control (PCLC) systems are vital for medical automation, patient monitoring, diagnosis, and therapy delivery.
  • Current PCLC systems show promise for critical care but face limitations in design, endpoint selection, safety, and assessment.
  • These limitations hinder the full potential of PCLC in improving patient outcomes and well-being.