Related Experiment Video

Updated: Jan 10, 2026

Particle Agglutination Method for Poliovirus Identification
07:06

Particle Agglutination Method for Poliovirus Identification

Published on: April 20, 2011

15.9K

[When AIHA does not explain everything: parvovirus B19 infection and pancytopenia as a differential diagnostic

W Harms1, R Akdas2, C Jacob3

  • 1Klinik für Hämatologie und medizinische Onkologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. wilken.harms@med.uni-goettingen.de.

Innere Medizin (Heidelberg, Germany)
|November 25, 2025
PubMed

A 48-year-old female patient with known autoimmune hemolytic anemia (AIHA) presented with severe anemia and pancytopenia. Despite typical hemolysis parameters and a positive direct antiglobulin test confirming the presence of warm autoantibodies, erythropoiesis was found to be hyporegenerative. This constellation suggested a combined mechanism of increased erythrocyte destruction and impaired hematopoietic capacity. Further diagnostic workup revealed active parvovirus B19 infection. This case highlights that the coincidence of AIHA and parvovirus B19 infection can lead to an atypical hematologic presentation and significantly complicate the diagnostic process.

Keywords:
Autoimmune hemolytic anemiaCoombs testErythropoiesisHemolysisPancytopenia

More Related Videos

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.2K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.2K

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.9K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
765