Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

2.2K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
2.2K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.1K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.1K
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

36.2K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
36.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Fattening mother's milk with oxytocin.

Science signaling·2026
Same author

RXRα marks the spot for Crohn's disease.

Science signaling·2026
Same author

A hostile environment for a commensal.

Science signaling·2026
Same author

Softer nuclei for whiter brown fat.

Science signaling·2025
Same author

A sphingomyelin shield for flaviviruses.

Science signaling·2025
Same author

The dose makes the poison.

Science signaling·2025
Same journal

ZNRF3 and RNF43 are active monomeric E3 ubiquitin ligases that self-associate.

Science signaling·2026
Same journal

Allosteric ligands with distinct properties uncover tissue-specific physiological regulation mediated by free fatty acid receptor 2.

Science signaling·2026
Same journal

Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate.

Science signaling·2026
Same journal

The APC/C adaptor Cdh1 stabilizes STING to potentiate innate immune activation in renal cell carcinoma.

Science signaling·2026
Same journal

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B.

Science signaling·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

14.1K

The fatty acid method for regrowing hair.

Wei Wong1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|November 25, 2025
PubMed
Summary
This summary is machine-generated.

Fatty acids from fat cells activate stem cells in hair follicles after skin injury. This discovery offers new insights into skin repair and hair regeneration mechanisms.

More Related Videos

Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes
12:11

Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes

Published on: August 27, 2015

20.8K
A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.4K

Related Experiment Videos

Last Updated: Jan 10, 2026

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

14.1K
Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes
12:11

Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes

Published on: August 27, 2015

20.8K
A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.4K

Area of Science:

  • Dermatology and Regenerative Medicine

Background:

  • Hair follicle stem cells are crucial for hair regeneration.
  • Skin injury triggers complex cellular responses.
  • Adipocytes (fat cells) play roles beyond energy storage.

Purpose of the Study:

  • To investigate the role of adipocyte-derived factors in activating hair follicle stem cells post-injury.
  • To elucidate the signaling pathways involved in wound-induced hair growth.

Main Methods:

  • Utilized mouse models of skin injury.
  • Analyzed gene and protein expression in hair follicles and surrounding tissues.
  • Investigated the effects of specific fatty acids on stem cell activity in vitro.

Main Results:

  • Skin injury led to the release of fatty acids from adipocytes.
  • These fatty acids were found to activate hair follicle stem cells.
  • Specific fatty acids promoted stem cell proliferation and differentiation, contributing to wound healing and hair regrowth.

Conclusions:

  • Adipocyte-derived fatty acids are key mediators in activating hair follicle stem cells following skin injury.
  • This mechanism represents a novel pathway for understanding and potentially enhancing hair regeneration.