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Double Parathyroid Carcinoma Associated With CDC73 Mutation: A Rare Case

Sandra Baptista1, Helena Leandro2, Catarina Gama3

  • 1Medical Oncology Department, Lisbon Portuguese Institute of Oncology Francisco Gentil, Lisbon, PRT.

Cureus
|November 26, 2025
PubMed
Summary

This case study highlights an extremely rare instance of malignant primary hyperparathyroidism in a middle-aged man. Diagnosis involved severe hypercalcemia, osteolytic lesions, and a confirmed CDC73 mutation, underscoring genetic links.

Keywords:
brown tumorscdc73 mutationhungry bone syndromeosteitis fibrosa cysticaparathyroid carcinomaprimary hyperparathyroidism

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