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Association Between Metabolic Syndrome and Risk of Laryngeal Cancer: A Systematic Review
Faizan Bashir1, Supriya Peshin2, Moniza Rafiq3
1School of Medicine, Shiraz University of Medical Sciences, Shiraz 71345-3119, Iran.
Current Oncology (Toronto, Ont.)
|November 26, 2025
Summary
Metabolic syndrome (MetS) may increase laryngeal cancer risk, particularly in Korean populations, though evidence varies globally. Further research is needed to confirm this association and its underlying mechanisms.
Area of Science:
- Oncology
- Epidemiology
- Metabolic Disorders
Background:
- Metabolic syndrome (MetS) is a major global health issue linked to cardiovascular disease, diabetes, and cancer.
- The association between MetS and laryngeal cancer is not well understood.
- Chronic inflammation, insulin resistance, and hormone disruption are potential mechanisms linking MetS to cancer.
Purpose of the Study:
- To review observational studies on the association between metabolic syndrome and laryngeal cancer.
- To synthesize evidence regarding the risk of laryngeal cancer in individuals with MetS.
- To explore variations in this association across different populations.
Main Methods:
- Systematic literature search of PubMed/MEDLINE, Scopus, and Web of Science.
- Inclusion of five large population-based observational studies.
- Risk of bias assessment using the Joanna Briggs Institute checklist.
Main Results:
- Three Korean cohort studies consistently showed MetS increased laryngeal cancer risk (HR 1.13-1.32), independent of smoking and alcohol.
- Hypertension and hyperglycemia were key MetS components linked to higher risk; chronic MetS showed the highest hazard.
- Western cohorts (UK Biobank, SEER-Medicare) reported null or inverse associations, indicating population-specific effects.
Conclusions:
- Evidence suggests a potential link between MetS and laryngeal cancer risk, but findings are inconsistent across populations.
- Korean studies indicate increased risk, while Western studies do not replicate this pattern.
- The certainty of evidence is low to moderate, requiring cautious interpretation and validation in diverse populations.
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