Related Experiment Video
Updated: Jul 17, 2026
12:00
Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
12.9K
Vaterite/Fucoidan Hybrid Microparticles: Fabrication, Loading of Lactoferrin, Structural Characteristics and
Daniil V Mosievich1,2, Nadezhda G Balabushevich1, Pavel I Mishin1
1Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University, 1 Leninskiye Gory, 119991 Moscow, Russia.
Marine Drugs
|November 26, 2025
Summary
Fucoidan enhances vaterite microparticles for drug delivery. These hybrid microparticles effectively immobilize and deliver therapeutic proteins like lactoferrin, showing stability and mucoadhesive properties.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Marine Biotechnology
Background:
- Fucoidan, a sulfated polysaccharide from brown seaweed, is explored for advanced drug carrier applications.
- Calcium carbonate vaterite microparticles offer a versatile platform for biomolecule immobilization.
- Developing novel carriers for therapeutic proteins is crucial for effective disease treatment.
Purpose of the Study:
- To investigate the properties of hybrid vaterite microparticles incorporating fucoidan and lactoferrin.
- To evaluate the loading efficiency, stability, and release kinetics of these hybrid microparticles.
- To assess the mucoadhesive, anticoagulant, and antibacterial activities of the developed microcarriers.
Main Methods:
- Co-precipitation of fucoidan from *Fucus vesiculosus* with vaterite microparticles.
- Loading of recombinant human lactoferrin into fucoidan-vaterite hybrid microparticles.
- Characterization of microparticle size, surface area, pore size, and ζ-potential.
- Assessment of lactoferrin incorporation efficiency, in vitro release profiles, mucoadhesion, anticoagulant, and antibacterial activities.
Main Results:
- Hybrid microparticles exhibited smaller diameter, larger surface area, and smaller pore size compared to control vaterite.
- Co-precipitation resulted in higher lactoferrin incorporation efficiency than protein adsorption.
- Microparticles demonstrated stability in acidic conditions, sustained release at pH 7.4, mucoadhesion, anticoagulant activity, and antibacterial effects against *Bacillus subtilis*.
Conclusions:
- Fucoidan-modified vaterite microparticles serve as a promising platform for therapeutic protein delivery.
- The hybrid microparticles exhibit favorable characteristics for drug carrier applications, including enhanced stability and functionality.
- This approach offers a novel strategy for the microfabrication of effective protein-based therapeutic agents.
Related Concept Videos
01:15Fineness of Cement
The fineness of cement directly influences the rate of hydration, as the hydration begins at the surface of the cement particles. In addition to hydration, the fineness of cement is vital for various properties of concrete including workability, gypsum requirement, and long-term behavior. The fineness of cement is represented in terms of the specific surface of cement which is typically measured in square meters per kilogram, with several methods available for this determination.
Direct...
Direct...
01:19Fineness Modulus
The fineness modulus (FM) of aggregate is a numerical index that measures the coarseness or fineness of the particles. It is calculated by adding the cumulative percentages of aggregate retained on each of a specified series of sieves and dividing the sum by 100.
Consider performing sieve analysis on sand through a set of ASTM sieves. The weight of aggregate retained in each sieve and pan placed at the bottom is recorded, as given in Column B of Table 1.
To determine the fineness modulus of...
Consider performing sieve analysis on sand through a set of ASTM sieves. The weight of aggregate retained in each sieve and pan placed at the bottom is recorded, as given in Column B of Table 1.
To determine the fineness modulus of...
01:23Pore Size Distribution
In concrete, the pore size distribution significantly influences the material's properties. Capillary pores, markedly larger than gel pores, form a vast network within partially hydrated cement paste, reducing the concrete's strength and increasing its permeability. This heightened permeability leads to a greater risk of damage from environmental factors like freeze-thaw cycles and chemical attacks, with the extent of vulnerability also being tied to the water-to-cement ratio.
Adequate...
Adequate...
01:22Fiber Reinforced Concrete
Fiber-reinforced concrete significantly enhances the structural and nonstructural properties of traditional concrete by incorporating fibers like steel, glass, and polymers. These fibers, varying from natural ones such as sisal and cellulose to manufactured ones like polypropylene and Kevlar, are mixed into hydraulic cement with aggregates. Steel fibers, often preferred for their robustness, contribute to improved ductility, toughness, and post-cracking performance. The concrete is classified...
01:30Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
01:29Additives and Fillers in Concrete
Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...
The...