Dose-Dependent Analysis of Image Quality in Pediatric Head CT Scans Across Different Scanners to Optimize Clinical...

Optimization of pediatric head computed tomography (CT) protocols is essential to minimize radiation exposure while maintaining diagnostic image quality. Previous studies mainly relied on phantom-based measurements or visual assessments, and validation using clinical images remains limited. This study aimed to establish quantitative thresholds for noise and contrast-to-noise ratio (CNR) in pediatric head CT by integrating multicenter clinical data with phantom evaluations.

A multicenter retrospective study was conducted using CT systems from eight hospitals, combined with Catphan phantom experiments and pediatric head CT data. Scan parameters, automatic exposure control settings, and reconstruction methods were collected. Image quality was quantified by the standard deviation (SD) of noise and CNR obtained from regions of interest in gray and white matter. Radiation dose was represented by CTDIvol. Relationships among CTDIvol, SD, and CNR were analyzed across scanners from three manufacturers (Canon, FUJI, and GE).

Consistent dose-response trends were observed across institutions and manufacturers. Image noise decreased as CTDIvol increased, but reached a plateau at higher doses. CNR improved with dose escalation, then stabilized. Both phantom experiments and clinical analyses identified a target SD of 5 and CNR of 2 as optimal indicators for pediatric head CT.

Quantitative thresholds were determined as practical indicators for balancing diagnostic image quality with dose reduction. Further reduction may be achieved through advanced reconstruction methods, such as deep learning-based algorithms. These findings may contribute to standardizing pediatric head CT protocols and supporting safer and more effective diagnostic imaging.