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HMGB1 and Its Signaling Pathway in Osteosarcoma: Current Advances in Targeted Therapy.
Zhuosheng Liu1, Fucai Wang1, Zhihan Zhou1
1School of Medicine, Huaqiao University, Quanzhou 362021, China.
Current Issues in Molecular Biology
|November 26, 2025
Summary
High-mobility group protein B1 (HMGB1) fuels osteosarcoma growth and immune evasion. Targeting HMGB1 and its pathways shows promise for osteosarcoma treatment, though clinical use faces challenges.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- High-mobility group protein B1 (HMGB1) is implicated in various cancers.
- Its role in osteosarcoma (OS) pathogenesis and therapeutic potential requires comprehensive review.
Purpose of the Study:
- To review current research on HMGB1 and its signaling pathways in osteosarcoma.
- To discuss the therapeutic application potential of targeting HMGB1 in OS.
Main Methods:
- Systematic review of domestic and international studies on HMGB1 in osteosarcoma.
- Analysis of HMGB1's biological functions, signaling pathways, and intervention strategies.
Main Results:
- HMGB1 promotes OS cell proliferation, invasion, and immune escape via RAGE, TLR4, MAPK, NF-κB, and PI3K/AKT pathways.
- Interference with HMGB1 or its signaling axis demonstrates antitumor potential in preclinical models.
- Clinical translation is hindered by HMGB1's dual effects and OS tumor heterogeneity.
Conclusions:
- HMGB1 and its signaling pathways represent crucial therapeutic targets for osteosarcoma.
- Future strategies may involve multi-channel interventions and advanced delivery systems for improved efficacy.
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