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Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
Published on: April 25, 2025
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Lacrimal Sac Tumors: A Histotype-Driven Literature Review
Luca Giovanni Locatello1, Enrico Redolfi De Zan2, Riccardo Marzolino1
1Department of Otorhinolaryngology, Academic Hospital "Santa Maria della Misericordia", Azienda Sanitaria Universitaria Friuli Centrale, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.
Cancers
|November 27, 2025
Summary
Lacrimal sac tumors (LSTs) are rare and difficult to diagnose. Complete surgical excision is crucial for treatment, despite diverse histology and evolving therapeutic strategies.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Lacrimal sac tumors (LSTs) are rare, posing diagnostic and therapeutic challenges.
- Limited understanding of LST biology and histology complicates treatment planning.
Purpose of the Study:
- To provide a comprehensive overview of recent literature on lacrimal sac tumors.
- To synthesize current knowledge on LST diagnosis, histology, and treatment strategies.
Main Methods:
- A 5-year scoping review of Cochrane Library, PubMed, and Google Scholar.
- Data extraction by three independent reviewers, with findings summarized due to heterogeneity.
Main Results:
- 55 articles were included, revealing diverse LST histology and no standard staging system.
- New biological insights offer novel treatment options, but endoscopic resection is limited to select non-aggressive cases.
- Complete excision remains the primary treatment modality.
Conclusions:
- A high index of suspicion is necessary for diagnosing rare LSTs.
- Histotype-driven treatment plans are essential, with complete excision as the cornerstone of management for all LSTs.
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