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Updated: Jul 1, 2026
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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
3.9K
Harnessing Copper Nanoparticles for Antimicrobial Applications: Advances and Challenges.
Diogo S Pellosi1, Giovanna S M Paiva2, Vitor G Vital2
1Chemistry Department, Federal University of Paraná (UFPR), Curitiba 81531-980, PR, Brazil.
Antibiotics (Basel, Switzerland)
|November 27, 2025
Summary
Copper nanoparticles (CuNPs) show potent antimicrobial activity against diverse pathogens, offering a promising alternative to antibiotics. However, careful consideration of their toxicity and environmental impact is crucial for safe application.
Area of Science:
- Nanotechnology
- Materials Science
- Microbiology
Background:
- Antimicrobial resistance (AMR) is a critical global health challenge.
- Copper nanoparticles (CuNPs) offer broad-spectrum antimicrobial properties and cost-effectiveness.
- CuNPs have potential applications in medicine, agriculture, and industry.
Purpose of the Study:
- To systematically review advances in CuNP synthesis.
- To explore CuNP antimicrobial mechanisms and applications.
- To assess CuNP-associated toxicity and ecotoxicity.
Main Methods:
- Comprehensive literature review of synthesis, mechanisms, applications, and toxicity.
- Comparative analysis of research findings.
- Focus on cytotoxic and ecotoxicological aspects.
Main Results:
- CuNPs exhibit strong antimicrobial activity via ROS generation, membrane disruption, and DNA/protein interactions.
- Applications include medical devices, wound dressings, textiles, and packaging.
- Challenges include mammalian cell cytotoxicity, ecological risks, and lack of safety standards.
Conclusions:
- CuNPs are a promising strategy against AMR, with significant application potential.
- Controlled synthesis and functionalization are key to balancing efficacy and toxicity.
- Future research requires eco-friendly synthesis, standardized toxicity assessments, and regulatory frameworks.
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