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Recent advances in electrochemical sensors for the detection of anticancer drugs
Sevda Hasanova1, Eda Gumus2, Erhan Zor3
1Department of Nanoscience and Nanoengineering, Institute of Science, Necmettin Erbakan University, Konya, Türkiye.
Abstract:
The incidence and mortality rates of cancer are rapidly increasing worldwide. As the global population grows and ages, cancer has become a leading cause of death, partly due to significant reductions in mortality rates from stroke and coronary heart disease in many countries. Despite significant advances in cancer therapy, there is a substantial interest in developing new anticancer agents with different mechanisms of action, as cancer cells have developed resistance to current treatments. Noteworthy anticancer agents in this category include doxorubicin, 5-fluorouracil, and methotrexate among others. There has been a concerted effort to develop rapid, sensitive, and non-destructive methods for detecting the effects and mechanisms of anticancer drugs both in vitro and in vivo. Currently, methods such as mass spectrometry-based liquid chromatography (LC-MS), capillary electrophoresis (CE), and mass spectrometry-based gas chromatography (GC-MS) are still widely used to study anticancer drugs. However, electroanalytical techniques have recently gained popularity due to their higher sensitivity, greater selectivity, eco-friendliness, shorter analysis time, and lower cost. These techniques are now frequently used to detect anticancer drugs. Identifying anticancer drugs at low concentrations and with high sensitivity is crucial for tracking these medications. In this study, we discuss the recent advances in electrochemical sensors for the detection of anticancer drugs between 2019 and 2024.
Insights
Cancer treatment faces challenges from drug resistance. This study reviews electrochemical sensors, offering sensitive and rapid detection of anticancer drugs, crucial for effective cancer therapy development.
Area of Science:
- Analytical Chemistry
- Electrochemistry
- Pharmacology
Background:
- Global cancer incidence and mortality are rising, necessitating novel therapeutic strategies.
- Cancer cells develop resistance to existing treatments, driving demand for new anticancer agents.
- Accurate detection of anticancer drugs is vital for monitoring treatment efficacy and developing new therapies.
Purpose of the Study:
- To review recent advancements in electrochemical sensors for anticancer drug detection.
- To highlight the advantages of electroanalytical techniques over traditional methods.
- To cover the period from 2019 to 2024 for emerging trends.
Main Methods:
- Review of scientific literature on electrochemical sensors and anticancer drug detection.
- Analysis of studies focusing on sensitivity, selectivity, and speed of detection methods.
- Comparison of electroanalytical techniques with conventional methods like LC-MS, CE, and GC-MS.
Main Results:
- Electrochemical sensors demonstrate superior sensitivity, selectivity, and cost-effectiveness for anticancer drug detection.
- These techniques offer faster analysis times and are more environmentally friendly than traditional methods.
- Significant progress has been made in developing electrochemical sensors for various anticancer drugs between 2019 and 2024.
Conclusions:
- Electrochemical sensors represent a promising and rapidly evolving technology for detecting anticancer drugs.
- Their high sensitivity and efficiency are crucial for advancing cancer drug development and patient monitoring.
- Continued research in this area will likely lead to improved diagnostic tools and therapeutic outcomes.
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