Portable Device for Wound Care: An Electrosprayable Zinc Basic Salt-Tranexamic Acid Nanohybrid System

Portable, point-of-care wound dressings that combine rapid hemostasis with pro-regenerative cues are a clinical priority. We report two handy electrospinning strategies that integrate tranexamic acid-intercalated zinc basic salts (TXA-ZBS, via co-precipitation) with polycaprolactone (PCL) nanofibers: i) embedded (TXA-ZBS/PCL), formed by blending TXA-ZBS into the PCL spinning solution, and ii) surface-coated (TXA-ZBS@PCL), produced by electrospinning TXA-ZBS onto preformed PCL nanofiber mats. Both architectures preserve the mechanical integrity and conformal, spray-on deployability of PCL while enabling TXA delivery at the wound interface with concurrent Zn²⁺ release. In head-to-head testing, TXA-ZBS@PCL provided greater cumulative TXA availability with sustained, diffusion/ion-exchange-governed kinetics, consistent with direct aqueous access to surface-deposited TXA-ZBS, whereas TXA-ZBS/PCL exhibited a more diffusion-limited profile due to the polymer barrier. In vitro and in vivo wound models showed that the coated architecture supported faster hemostatic responses and improved wound-closure metrics relative to the embedded format. Taken together, these results identify surface-coated TXA-ZBS@PCL as the preferred design for localized, surface-constrained hemostasis, while the embedded configuration offers a more restricted release option when deeper diffusion is not desired. The comparative framework presented here guides selection of architecture for next-generation, handy portable wound device.