[Autoimmune progesterone dermatitis]

Autoimmune progesterone dermatitis (APD) is a rare, cyclic condition triggered by sensitisation to exogenous and/or endogenous progesterone. In this case report, we present a 44-year-old woman with presumed primary sensitisation from an intrauterine device, followed by cross-reactivity to endogenous progesterone. The patient experienced significant symptom relief following treatment with omalizumab. In conclusion, APD is diagnostically challenging due to its variable presentation, but treatment with omalizumab has shown promising results.