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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Advancing Diabetic Foot Ulcer Care: Focus on the Post-Healing Transition Phase
Kamran Shakir1,2, Hadi Sarlak1,2, Sicco A Bus3,4
1Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - Università di Bologna, Bologna, Italy.
Journal of Diabetes
|November 28, 2025
Summary
Diabetic foot ulcer (DFU) recurrence is common due to altered tissue mechanics post-healing. This review highlights the need for better transition phase strategies focusing on tissue vulnerability and pressure relief to prevent re-ulceration.
Area of Science:
- Biomedical Engineering
- Diabetology
- Wound Healing Research
Background:
- Diabetic foot ulcers (DFUs) frequently recur, causing significant morbidity and healthcare costs.
- Current healing criteria focus on re-epithelialization, overlooking altered plantar tissue mechanics that increase recurrence risk.
Purpose of the Study:
- To review the critical 'transition phase' after DFU healing.
- To explore the role of tissue mechanics and offloading strategies during this vulnerable period.
Main Methods:
- An extensive PubMed search identified studies on plantar tissue mechanics and post-healing preventative strategies.
- 57 studies were included after title and abstract screening.
Main Results:
- Most research focuses on offloading during remission, neglecting the physiological needs of plantar soft tissues post-healing.
- A lack of differentiation between re-ulceration and recurrent ulceration was noted.
Conclusions:
- There is a critical need for advanced solutions addressing pressure relief and footwear adherence.
- Future strategies must consider the dynamic physiological conditions of tissues during the transition phase and varying patient risk factors.
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