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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Pneumococcal disease without apparent pulmonary involvement]
Sofía Solano1, Ayelen Arcangeli1, Belén Murillo Echegaray1
1Servicio de Clínica Médica, Clínica Santa Isabel, Buenos Aires, Argentina.
Abstract:
Spinal epidural abscess (SEA) is a classically monomicrobial infection most commonly caused by Staphylococcus aureus (∼65%), followed by Gram-negative bacilli (∼16%), and less frequently by Gram-positive diplococci such as Streptococcus pneumoniae (∼7%), which typically reach the epidural space hematogenously from another focus, mainly respiratory. SEA can originate from hematogenous seeding or direct inoculation, and in approximately one-third of cases, the source of infection cannot be identified. We present a clinical case of SEA associated with pneumococcal bacteremia. A 65-year-old woman with no relevant medical history presented with a 48-hour history of right-sided lower back pain, rendering her unable to sit or stand, with radiation to the thigh and associated fever. A contrast-enhanced magnetic resonance imaging of the spine revealed 5 and 6 mm collections in the posterior epidural space at the L4 and L5 levels. Blood cultures grew multi-sensitive S. pneumoniae, prompting initiation of antibiotic therapy with good clinical response. The traumatology team assessed the patient and obtained a sample from the larger collection, which also yielded the same pathogen. Isolated pneumococcal spinal infection is a rare but extremely serious condition, with a mortality rate exceeding 20%, and can lead to significant neurological consequences if not managed through a multidisciplinary approach involving broad-spectrum antibiotics and, in some cases, surgical intervention.
Insights
Spinal epidural abscess (SEA) is rare but serious. This case highlights Streptococcus pneumoniae as a cause, emphasizing prompt diagnosis and multidisciplinary treatment for better outcomes.
Area of Science:
- Infectious Diseases
- Neurosurgery
- Radiology
Background:
- Spinal epidural abscess (SEA) is typically monomicrobial, often caused by Staphylococcus aureus.
- Streptococcus pneumoniae is an infrequent cause of SEA, usually originating from hematogenous spread.
- Identifying the source of infection in SEA can be challenging, occurring in about one-third of cases.
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