Correlation between anti-Müllerian hormone, hypertension and vascular age: the Generation R Study, a population-based...

Area of Science:

• Endocrinology
• Cardiovascular Health
• Reproductive Medicine

Background:

• Anti-Müllerian hormone (AMH) is a key indicator of ovarian reserve.
• Vascular aging and hypertension are significant public health concerns.
• The relationship between AMH levels and cardiovascular health markers requires further investigation.

Purpose of the Study:

• To investigate the association between anti-Müllerian hormone (AMH) levels and the risk of developing hypertension.
• To explore the link between AMH levels and vascular aging, using carotid artery intima-medial thickness (CIMT) as a proxy.
• To analyze these relationships within a large, population-based prospective cohort.

Main Methods:

• The study utilized data from the Generation R Study, a prospective cohort in Rotterdam, Netherlands.
• Associations between AMH levels and hypertension were analyzed in 4,883 women.
• Vascular age was assessed using CIMT measurements in 3,508 women, correlating it with AMH levels.

Main Results:

• Lower AMH percentiles were significantly associated with an increased risk of hypertension.
• Women in the lowest AMH percentile (p90).
• Vascular age was substantially older than chronological age in women with low AMH levels, indicating accelerated vascular aging.

Conclusions:

• Low AMH levels, independent of age, are associated with hypertension and indicators of vascular alterations.
• Diminished ovarian reserve may signal increased risk for cardiovascular diseases.
• AMH could potentially serve as an early predictive marker for cardiovascular disease, warranting counseling on preventive measures for women with low AMH.