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Updated: Jan 9, 2026

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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High-Risk Prostate Cancer in a Patient with Untreated Prolactinoma and Castrate-Level Testosterone Suppression: A
Tara A Seibert1, Afreen Shariff2,3, Hannah D McManus4,5
1Department of Medicine, Duke University Hospital, Durham, NC, USA.
Case Reports in Oncology
|December 1, 2025
Summary
Patients with prolactinomas, which cause low testosterone, can still develop prostate cancer (PCa). Careful treatment selection is crucial to manage hormonal interactions and avoid complications like pituitary apoplexy.
Area of Science:
- Endocrinology
- Urology
- Oncology
Background:
- Prolactinomas can cause hypogonadism by disrupting the hypothalamic-pituitary-gonadal axis, leading to castrate-level testosterone suppression.
- While hypogonadism generally reduces prostate cancer (PCa) risk, PCa can still develop through nonclassical pathways.
- Managing patients with both prolactinoma and PCa requires careful consideration of the hormonal interplay between prolactin and testosterone.

