Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.9K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K
Causality in Epidemiology01:21

Causality in Epidemiology

1.5K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.5K
Pleiotropy01:33

Pleiotropy

43.1K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.1K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

680
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
680

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

All-solid-state electrochromic devices based on ultra-thin Li<sub>3</sub>PO<sub>4</sub> electrolyte.

Chemical communications (Cambridge, England)·2026
Same author

Learning fair representation for fine-tuning pre-trained language models.

Neural networks : the official journal of the International Neural Network Society·2026
Same author

Omics-based computational approaches for biomarker identification, prediction, and treatment of Long COVID.

Critical reviews in clinical laboratory sciences·2025
Same author

Learning instrumental variable representation for debiasing in recommender systems.

Neural networks : the official journal of the International Neural Network Society·2025
Same author

Stable Breast Cancer Prognosis.

IEEE transactions on computational biology and bioinformatics·2025
Same author

Leveraging Channel Coherence in Long-Term iEEG Data for Seizure Prediction.

IEEE journal of biomedical and health informatics·2025

Related Experiment Video

Updated: Jan 9, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K

Integrative multi-omics framework for causal gene discovery in Long COVID.

Sindy Pinero1, Xiaomei Li2, Lin Liu1

  • 1UniSA STEM, University of South Australia, Adelaide, South Australia, Australia.

Plos Computational Biology
|December 1, 2025
PubMed
Summary

Long COVID, or Post-Acute Sequelae of SARS-CoV-2 infection (PASC), has poorly defined genetic risk factors. This study identifies 32 candidate genes and three distinct Long COVID subtypes using a multi-omics framework, advancing precision medicine.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

Related Experiment Videos

Last Updated: Jan 9, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

Area of Science:

  • Genetics
  • Immunology
  • Computational Biology

Background:

  • Long COVID (Post-Acute Sequelae of SARS-CoV-2 infection) affects 10-20% of COVID-19 survivors with persistent multisystem symptoms.
  • Genetic factors contributing to Long COVID risk are not well understood, despite known demographic and clinical risk factors.

Purpose of the Study:

  • To identify causal genes and network drivers of Long COVID using an integrated multi-omics approach.
  • To elucidate the genetic architecture and heterogeneity of Long COVID.
  • To discover potential therapeutic targets for Long COVID.

Main Methods:

  • Developed a multi-omics framework integrating Transcriptome-Wide Mendelian Randomization (TWMR), Control Theory (CT), eQTL, GWAS, RNA-seq, and Protein-Protein Interaction (PPI) networks.
  • Prioritized candidate genes involved in viral response, carcinogenesis, immune regulation, and cell cycle control.
  • Performed enrichment analyses and identified Long COVID subtypes based on causal gene expression.

Main Results:

  • Identified 32 candidate genes, including 13 novel, implicated in Long COVID pathogenesis.
  • Revealed shared genetic architecture with syndromic, metabolic, autoimmune, and connective tissue disorders.
  • Discovered three distinct symptom-based Long COVID subtypes, highlighting disease heterogeneity.
  • Developed an open-source Shiny application for data exploration.

Conclusions:

  • The integrative framework identified novel causal mechanisms and therapeutic targets for Long COVID.
  • Findings advance precision medicine strategies for Long COVID by characterizing subtypes and underlying genetic drivers.
  • Understanding genetic underpinnings is crucial for developing targeted Long COVID treatments.