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Updated: Jan 9, 2026

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
Repurposing of microbial proteins as new-generation therapeutic agents for biomedical applications
Sivapriya Pavuluri1, Rajesh Kotcherlakota1, Sangita Mukhopadhyay1
1Laboratory of Molecular Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Inner Ring Road, Uppal, Hyderabad, 500039, Telangana, India.
None:
Microbial pathogens have developed diverse strategies to exploit the host immune system because of their long period of coevolution with the target hosts. A deeper understanding of these mechanisms, particularly the role of microbial virulence proteins (MPs) in modulating host immune defense mechanisms, has opened new avenues for devising innovative therapeutic strategies. Several MPs are now being repurposed for the treatment of a range of clinical conditions including anti-inflammatory, anticancer, antimicrobial, antithrombotic, antidiabetic, and kidney-related diseases. Some of these therapies are currently in clinical trials or in clinical use. This review highlights recent advances in repurposing MPs as therapeutics and their growing clinical relevance.
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