Related Experiment Video
Updated: Jan 9, 2026
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
A Three-Intervention Evidence-Based Bundle to Reduce Chorioamnionitis Among Patients with Prelabor Rupture of
Background:
Chorioamnionitis has serious maternal-newborn risks. Risk factors include prelabor rupture of membranes (PROM), vaginal exams, and inadequate perineal hygiene. There may be opportunities to reduce chorioamnionitis with PROM and newborns affected by chorioamnionitis within the Joint Commission Measure of Unexpected Newborn Complications (PC-06) using an infection prevention bundle.
Problem:
An internal audit found an increased incidence of newborns born to women with chorioamnionitis. Patients with PROM had a 6.2% chorioamnionitis rate compared to a 3.6% overall chorioamnionitis rate.
Interventions:
A quality improvement project using an infection prevention bundle for PROM was implemented using three interventions: avoiding unnecessary vaginal exams in PROM diagnosis, hourly pericare with peripad changes, and hand hygiene compliance.
Results:
Data were compared from first quarter 2023 before bundle implementation through third quarter 2023 post bundle implementation. The rate of chorioamnionitis was decreased among patients with PROM from 8.1% (9/111) in first quarter 2023 to 3.1% (4/126) in third quarter 2023. There were fewer newborns affected by chorioamnionitis within PC-06, from 9% (3/32) in first quarter 2023 to 7% (3/46) in third quarter 2023. PROM with chorioamnionitis within PC-06 was 0% (0/32) at first and (0/46) third quarter 2023.
Conclusions:
Bundle adherence with PROM could help decrease chorioamnionitis and contribute to fewer newborn complications related to chorioamnionitis.
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