Clinical Profile, Management and Visual Outcomes in Patients with Sarcoid Posterior Uveitis

Area of Science:

• Ophthalmology
• Immunology

Background:

• Sarcoid posterior uveitis (SPU) is a significant cause of visual morbidity.
• Understanding its demographic profile, clinical features, and outcomes is crucial for effective management.

Purpose of the Study:

• To determine the demographic profile, clinical features, investigative results, management, lesion-specific outcomes, complications, and follow-up of diagnosed sarcoid posterior uveitis (SPU) cases.
• To analyze lesion-specific visual prognosis and clinical response to treatment in SPU patients.

Main Methods:

• A retrospective observational study was conducted.
• Data from SPU cases were extracted from electronic medical records at a tertiary care center in India.

Main Results:

• Seventy-two eyes of 43 patients were analyzed, with choroidal granulomas being the most common lesion (62%).
• Steroids and immunosuppressives (IMT) were the primary treatments. Visual acuity (BCVA) was stable in 75% of followed eyes.
• Outcomes were better for retinal vasculitis and choroidal granulomas compared to multifocal choroiditis.

Conclusions:

• Sarcoid posterior uveitis is linked to considerable visual morbidity.
• Prompt identification and treatment with steroids and IMT can lead to uveitis resolution and vision improvement.
• The visual prognosis and treatment response are dependent on the specific lesion subtype of SPU.