DNA Self-Assembly on Lithographic Patterns: Fabrication Methods

Area of Science:

• Nanotechnology
• Surface Science
• Materials Science

Background:

• Structural DNA nanotechnology and lithographic patterning are merging for device applications.
• Recent advances allow deterministic placement and assembly of DNA nanostructures on surfaces.

Purpose of the Study:

• To review fabrication strategies for DNA self-assembly on patterned substrates.
• To highlight advances and challenges in combining DNA nanotechnology and lithography.

Main Methods:

• Designing and depositing DNA nanostructures for surface self-assembly.
• Fabricating patterned surfaces using lithography and chemical functionalization.

Main Results:

• Demonstrated applications in field-effect transistors, photodiodes, plasmonic metasurfaces, quantum light sources, nanomachines, and sensor arrays.
• Enabled hierarchical architectures through on-surface assembly of DNA nanostructures.

Conclusions:

• The synergy of DNA nanotechnology and lithography is crucial for next-generation nanoscale devices.
• Key challenges remain in fabrication and integration across optoelectronics, quantum technologies, and biotechnology.