Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

934
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
934
Polygenic Traits01:18

Polygenic Traits

68.8K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
68.8K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraocular Pressure Measurement Variability in the Ocular Hypertension Treatment Study.

Ophthalmology. Glaucoma·2026
Same author

Toward Long-Term Visual Field Appearance Forecasting Using Artificial Intelligence for Ophthalmic Education and Diagnosis.

Ophthalmology science·2026
Same author

Multi ancestry genome wide association meta analysis of urinary aMT6s levels.

Scientific reports·2026
Same author

Larger Real-World OCT Reference Database Improves Accuracy of Glaucoma Flagging Using Summary Metrics.

Translational vision science & technology·2026
Same author

Characterization of Temporal Delay and Modeling of Intraocular Pressure and Visual Field Progression in the African Descent and Glaucoma Evaluation Study.

Ophthalmology. Glaucoma·2026
Same author

Deep-learning-derived glaucoma-related endophenotypes enable novel genome-wide genetic and functional discovery.

Research square·2026
Same journal

Pathogenicity Analysis of Two Novel CRB1 Mutations in Three Chinese Inherited Retinal Dystrophy Families and a Literature Review.

Translational vision science & technology·2026
Same journal

Gas-Lesion Contact and Postural Compliance After Vitrectomy With Tamponade: A Continuous Monitoring and 3D Quantitative Analysis.

Translational vision science & technology·2026
Same journal

Automated Deep Learning Quantification of Avascular Area and Intravitreal Neovascularization in Retinal Flatmounts of Rodent Oxygen-Induced Retinopathy Models.

Translational vision science & technology·2026
Same journal

The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.

Translational vision science & technology·2026
Same journal

Deep-ZOMA: A Deep Learning-Based Approach for Automated Morphometric Analysis of Zebrafish Larvae Ocular Structures.

Translational vision science & technology·2026
Same journal

Investigating the Correlation Between Choroidal Alteration and Visual Function Metrics in Dysthyroid Optic Neuropathy.

Translational vision science & technology·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K

Dual-Level Pattern Tree for Visual Field Improves Glaucoma Progression and Polygenic Risk Prediction.

Luo Song1, Lucy Q Shen2, Louis R Pasquale3

  • 1Harvard Ophthalmology AI Lab, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Translational Vision Science & Technology
|December 4, 2025
PubMed
Summary
This summary is machine-generated.

A new dual-level pattern tree effectively characterizes visual field (VF) loss subtypes, improving prediction of glaucoma progression and polygenic risk scores (PRSs). This advanced classification offers better insights into glaucoma subtypes for patient management and research.

More Related Videos

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.2K

Related Experiment Videos

Last Updated: Jan 9, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.2K

Area of Science:

  • Ophthalmology
  • Genetics
  • Data Science

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Accurate characterization of visual field (VF) loss is crucial for predicting glaucoma progression.
  • Existing methods may not fully capture the complexity of VF loss patterns.

Purpose of the Study:

  • To develop a dual-level pattern tree for classifying VF loss subtypes.
  • To enhance the prediction of glaucoma progression using these subtypes.
  • To correlate VF patterns with glaucoma polygenic risk scores (PRSs).

Main Methods:

  • Archetypal analysis was used to cluster 24-2 VFs into trunk and branch patterns.
  • Cox regression models forecasted VF progression using various slope metrics.
  • Multivariable regression analyses linked VF patterns with glaucoma PRSs.

Main Results:

  • Identified 17 trunk patterns and 169 branch patterns, forming trunk-branch (T-B) classifications.
  • T-B patterns significantly outperformed trunk-only patterns in predicting 5-year progression across multiple metrics.
  • T-B patterns demonstrated superior predictive capability for glaucoma PRSs.

Conclusions:

  • Dual-level trunk-branch VF classifiers are more effective than trunk-only classifications for predicting functional progression and glaucoma PRS.
  • This approach offers a more nuanced understanding of glaucoma subtypes.
  • Improved VF characterization can aid in personalized glaucoma management and research.