Intelligent circuit exercise training improves platelet mitochondrial bioenergetic efficiency in sedentary men
Ai Yin Lim1, Chi-Yao Chiang1, Yu-Ting Lin1
1Healthy Aging Research Center, Graduate Institute of Rehabilitation Sciences, Chang Gung University, 259 Wen-Hwa 1St Road, Kwei-Shan, Taoyuan, 333, Taiwan.
European Journal of Applied Physiology
|December 4, 2025
Summary
Circuit exercise (CET) and single exercise (SET) improve aerobic fitness and enhance platelet mitochondrial function in sedentary men. These exercise regimens boost FADH2-dependent pathways, positively impacting thrombotic risk factors.
Area of Science:
- Exercise physiology
- Mitochondrial bioenergetics
- Platelet function
Background:
- Platelet mitochondria play a role in thrombogenesis.
- Regular exercise is known to reduce vascular thrombotic risks.
- The impact of specific exercise regimens on platelet mitochondrial bioenergetics requires further investigation.
Purpose of the Study:
- To investigate the effects of circuit (CET) and single exercise (SET) regimens on platelet mitochondrial bioenergetics in sedentary men.
- To compare the impact of CET and SET on systemic aerobic fitness and platelet mitochondrial function.
Main Methods:
- Fifty healthy sedentary men were randomized into CET, SET, or control groups.
- CET involved cycling, rowing, and elliptical ergometry; SET involved cycling.
- Systemic aerobic fitness (VO2max) and platelet mitochondrial electron transport system (ETS) and oxidative phosphorylation (OXPHOS) capacities were measured.
Main Results:
- Both CET and SET significantly improved VO2max.
- Acute exercise initially decreased platelet ETS and OXPHOS capacities.
- CET and SET interventions increased platelet FADH2-linked OXPHOS and ETS capacities.
- Improvements in VO2max correlated positively with enhanced platelet OXPHOS and ETS.
Conclusions:
- Both CET and SET enhance systemic aerobic capacity in sedentary males.
- These exercise regimens increase platelet FADH2-dependent OXPHOS and ETS capacities.
- Changes in systemic aerobic capacity are linked to improvements in platelet mitochondrial bioenergetics following intelligent exercise programs.
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