Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to Comment on: Assessing the Fragility of Statistically Significant Outcomes in Randomized Controlled Trials of Minimally Invasive Glaucoma Surgery (MIGS).

American journal of ophthalmology·2026
Same author

Assessing the Fragility of Statistically Significant Outcomes in Randomized Controlled Trials of Minimally Invasive Glaucoma Surgery (MIGS).

American journal of ophthalmology·2026
Same author

Predicting Variability and Reliability in Visual Field Testing: Short- and Long-Term Approaches.

Ophthalmology science·2026
Same author

Tobacco smoking is not associated with primary open-angle glaucoma: a systematic review and meta-analysis.

International ophthalmology·2026
Same author

Refining Visual Field Trend Progression Criteria in Glaucoma: Impact of Significance Thresholds and Test Frequency.

Ophthalmology. Glaucoma·2026
Same author

Using the Rate of Global and Pointwise Microperimetry Change to Predict Structural Conversion in Intermediate Age-Related Macular Degeneration.

Ophthalmology science·2025
Same journal

Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

American journal of ophthalmology·2026
Same journal

Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

American journal of ophthalmology·2026
Same journal

Forging Ahead: The Need for Improved Representation in Academic Ophthalmology.

American journal of ophthalmology·2026
Same journal

Clinical Utility of Ultra-Widefield Swept-Source OCT for Intraocular Tumors: Comparison With Ultrasonography, SD-OCT, and MRI.

American journal of ophthalmology·2026
Same journal

Therapeutic Advances in Corneal Scar management: Topical Treatments, Mesenchymal Cell Therapy and Stromal Transplantation.

American journal of ophthalmology·2026
Same journal

Increased Risk for Ocular Surface Neoplasia in Recipients of Solid Organ Transplant.

American journal of ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Vessel-sparing Excision and Primary Anastomosis
08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.9K

Risk Factors for Failure in Minimally Invasive Bleb Surgery: A Systematic Review.

Minsu Jung1, Ying Zhi Kong2, Abdus Samad Ansari3

  • 1From the Faculty of Medicine and Health, University of New South Wales (M.J., J.C.K.T.), Kensington, New South Wales, Australia.

American Journal of Ophthalmology
|December 4, 2025
PubMed
Summary
This summary is machine-generated.

Minimally invasive bleb surgery (MIBS) failure is linked to non-White ethnicity and reduced intraoperative Mitomycin-C (MMC) use. These factors, along with specific glaucoma types, may influence outcomes, but evidence certainty is low.

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.2K
Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

14.5K

Related Experiment Videos

Last Updated: Jan 9, 2026

Vessel-sparing Excision and Primary Anastomosis
08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.9K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.2K
Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

14.5K

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Surgical Outcomes

Background:

  • Minimally invasive bleb surgery (MIBS) offers a safer profile than traditional filtration surgery for reducing intraocular pressure (IOP).
  • Identifying risk factors for MIBS failure is crucial for improving patient selection and surgical success rates.

Purpose of the Study:

  • To systematically review and identify demographic and ophthalmic risk factors associated with surgical failure after minimally invasive bleb surgery (MIBS).

Main Methods:

  • A systematic review was conducted using Embase, Web of Science, and MEDLINE databases.
  • Included studies reported factors associated with MIBS failure, with risk of bias, evidence quality, and certainty of evidence evaluated.
  • Data from 18 studies (9580 eyes) on XEN Gel Stent and PreserFlo MicroShunt were analyzed.

Main Results:

  • Non-White ethnicity (Asian, non-Hispanic Black) and reduced/omitted intraoperative Mitomycin-C (MMC) were associated with higher failure risk (low certainty).
  • Glaucoma diagnosis showed conflicting associations with failure risk (very low certainty), with higher risks noted for pseudoexfoliative, pigmentary, angle closure, uveitic, and normal tension glaucoma.
  • Ocular hypertension and open-angle glaucoma suspects had a lower risk of failure.

Conclusions:

  • Demographic factors like non-White ethnicity and intraoperative MMC dosing are key predictors of MIBS failure.
  • While certain glaucoma subtypes may have higher failure rates, the low certainty of evidence necessitates cautious interpretation.
  • Findings can inform patient selection and guide future research in glaucoma surgery.