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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in hospitals have...
Patient-centered Care01:13

Patient-centered Care

Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
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Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:

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Related Experiment Video

Updated: May 12, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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Innovative Pathways for Advanced Practice Provider Growth: The Memorial Sloan Kettering Cancer Center Ascend Program.

Joanna Yohannes-Tomicich1, Linda D'andrea2, Xin Kenny Lin3

  • 1From Department of Anesthesiology & Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Journal of the Advanced Practitioner in Oncology
|December 5, 2025
PubMed
Summary

A new career advancement pathway for advanced practice providers (APPs) was created to boost clinical excellence and job satisfaction. This initiative aims to reduce turnover and improve retention in comprehensive cancer centers.

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Area of Science:

  • Oncology Nursing
  • Advanced Practice Provider Professional Development

Background:

  • Advanced practice providers (APPs) are crucial in comprehensive cancer centers.
  • There is a need to enhance APP career progression, job satisfaction, and retention.

Purpose of the Study:

  • To develop and implement a structured career advancement pathway for APPs.
  • To promote clinical excellence, job satisfaction, and retention among APPs at a major cancer center.

Main Methods:

  • A literature search was conducted using PubMed.
  • The Memorial Sloan Kettering Cancer Center (MSKCC) Advance Model was developed, integrating the Strong Model and Benner's Novice to Expert model.
  • The MSK Ascend Program was established based on this theoretical model.

Main Results:

  • The MSK Ascend Program provides a formal pathway for APP recognition and promotion.
  • The program encompasses seven domains: direct care, research, change leadership, education, publications, technology, and mentorship.
  • It supports continuous professional development and advancement of APP practice.

Conclusions:

  • Leadership support is vital for the program's success and sustainability.
  • The program fosters professional growth and satisfaction among APPs.
  • Iterative refinement demonstrates commitment to advancing the APP community.