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Published on: March 17, 2023
Red/NIR-emissive AIE nanoprobe to track subcellular dynamics in a photodynamic therapy process
Yu Zhou1, Yalei Jiang1, Lanqiong Zhang2
1School of Chemistry, Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China. xuyanzi@xjtu.edu.cn.
None:
Precise monitoring of cancer treatment at the subcellular level remains a critical challenge. Therefore, a lysosome-specific AIE nanoprobe integrating stimulated emission depletion (STED) imaging and photodynamic therapy is reported here. The probe enables real-time visualization of lysosomal dynamics and reactive oxygen species (ROS)-mediated apoptosis, offering a powerful platform for high-resolution imaging-guided cancer diagnosis and treatment.

