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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Diabetic Nephropathy01:28

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Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
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Diabetic Neuropathy01:22

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Related Experiment Video

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Nanozyme-Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy.

Rui Chen1, Yanguo Su1, Guiyuan Zhao1

  • 1Key Laboratory of Marine Drugs, Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotherapeutics, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 5, 2025
PubMed
Summary

A novel hydrogel therapy effectively treats diabetic osteoarthritis by targeting advanced glycation end-products (AGEs). This "restrain-restore-reinforce" strategy improves joint health and function in animal models.

Keywords:
cartilage repairheat shock protein 70mild photothermal therapynanozymessynovitis

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Advanced glycation end-products (AGEs) are key drivers in diabetic osteoarthritis (DOA) pathogenesis, causing cartilage damage and joint dysfunction.
  • Current treatments for DOA lack specific AGEs-targeting therapies, highlighting an unmet clinical need.

Purpose of the Study:

  • To develop a composite hydrogel (PTC-MP) utilizing a "restrain-restore-reinforce" (3R) strategy for AGEs-directed DOA therapy.
  • To evaluate the efficacy of PTC-MP hydrogel combined with mild photothermal therapy (mPTT) in a rat DOA model.

Main Methods:

  • Fabrication of a composite hydrogel incorporating polydopamine-coated tannic cerium (PTC) nanozymes and magnesium ions (Mg2+).
  • Assessment of PTC-MP hydrogel's ability to restrain AGEs formation via radical scavenging, ion chelation, and hydrophobic binding.
  • Evaluation of mPTT-induced restoration of cartilage homeostasis by mitigating AGEs-related reactive oxygen species (ROS) and mitochondrial dysfunction.
  • Investigation of Mg2+-mediated reinforcement of joint repair through hyaluronic acid (HA) secretion.

Main Results:

  • PTC-MP hydrogel demonstrated effective restraint of AGEs formation.
  • mPTT with PTC-MP hydrogel successfully restored cartilage homeostasis by reducing ROS and improving mitochondrial function.
  • Mg2+ promoted endogenous HA secretion, enhancing joint lubrication.
  • In vivo studies showed significant attenuation of DOA progression, reduced osteophytes, decreased synovial inflammation, and improved motor function in rats.

Conclusions:

  • The developed PTC-MP hydrogel with mPTT offers a promising "3R" therapeutic strategy for AGEs-targeted DOA treatment.
  • This approach effectively addresses cartilage degradation, joint lubrication, and motor function deficits associated with DOA.
  • The study provides a novel therapeutic avenue for managing recalcitrant diabetic osteoarthritis.