Capsaicin in the Management of Peripheral Neuropathy: A Review
Rabiul Ryan1, Ramzan Judge2, Jesse Lou1
1Department of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College, Thomas Jefferson University, 3 Crescent Drive, Philadelphia, PA, 19112, USA.
Current Pain and Headache Reports
|December 5, 2025
Summary
Capsaicin offers prolonged relief for neuropathic pain by targeting TRPV1 receptors. This topical treatment is effective and well-tolerated, showing significant pain reduction with fewer side effects than systemic options.
Area of Science:
- Pharmacology
- Neurology
- Pain Management
Background:
- Neuropathic pain is a debilitating condition with limited treatment options.
- Capsaicin, derived from chili peppers, is a natural compound known to interact with the TRPV1 receptor.
Purpose of the Study:
- To review the current evidence on the efficacy and safety of capsaicin for neuropathic pain.
- To update on capsaicin's role as a therapeutic agent in managing various neuropathies.
Main Methods:
- Literature review of studies investigating capsaicin for neuropathic pain.
- Analysis of clinical trial data comparing capsaicin to placebo and other treatments.
Main Results:
- Capsaicin provides significant pain relief in diabetic and non-diabetic neuropathies.
- It is non-inferior to pregabalin for peripheral neuropathy and superior to placebo.
- Topical application leads to fewer systemic adverse events, enhancing its safety profile.
Conclusions:
- Capsaicin is an effective and well-tolerated treatment for neuropathic pain.
- Its mechanism may involve nerve degeneration and regeneration.
- Capsaicin is a viable alternative for managing diverse neuropathic conditions.
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