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Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
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Unlocking human brain networks by assembling circuits in vitro and in vivo
1School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Cell Stem Cell
|December 5, 2025
Abstract
None:
In this issue of Cell Stem Cell, Wang et al.1 generate human nucleus basalis of Meynert organoids (hnbMOs), establish a human-specific cholinergic projection system in transplanted assembloids, and identify projection deficits in Down syndrome-derived assembloids. This study provides a valuable model for investigating nbM-related neural circuits and neurological disorders.
