Investigating the Timing Behavior of Compton Scattering in BGO for Time-of-Flight PET

Bismuth germanate (BGO) is gaining renewed attention as a viable material for hybrid Cherenkov/scintillation time-of-flight positron emission tomography (TOF-PET) detectors. While single-crystal studies have demonstrated excellent timing resolution by leveraging prompt Cherenkov photons, practical detector modules based on pixelated arrays introduce a high prevalence of inter-crystal scattering (InterCS) events, complicating timing accuracy. In this study, we experimentally investigated the impact of InterCS on BGO Cherenkov timing using a dual-pixel detector coupled to a segmented SiPM readout. Events were classified into full-energy deposition (FED; primary crystal 511 keV absorption), InterCS, and penetration types via energy-weighted positioning and validated using GATE simulations, which also revealed that over 25% of the experimentally identified full-energy events involved intra-crystal scatter (IntraCS). For InterCS events, the optimal timestamp selection was achieved by choosing the earlier of the two timestamps, yielding a coincidence timing resolution of 221 ps FWHM (831 ps FWTM)-markedly worse than the 184 ps (603 ps FWTM) obtained for FED events. Furthermore, prompt photon yield was found to decrease measurably due to energy splitting: InterCS events averaged 4.73 detected photons in the first 1 ns, compared to 5.76 for FED events. These results emphasize the importance of incorporating time-aware, per-pixel timestamping strategies in pixelated BGO TOF-PET systems to maintain optimal timing performance in the presence of scatter.