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Updated: Jan 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Delving Into PubMed Records: How AI-Influenced Vocabulary has Transformed Medical Writing since ChatGPT
1Department of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira-shi, Tokyo, 187-8551, Japan.
Certain words and phrases commonly used by large language models (LLMs) like ChatGPT have increased in medical literature. This trend predates ChatGPT, suggesting LLMs amplify existing vocabulary patterns rather than creating new ones.
Area of Science:
- Medical Literature Analysis
- Natural Language Processing
- Academic Writing Trends
Background:
- Large language models (LLMs), including ChatGPT, are increasingly utilized in academic writing.
- Concerns exist regarding the potential homogenization of scientific language due to AI tool usage.
- This study investigates the prevalence of specific LLM-associated terms in medical research.
Purpose of the Study:
- To determine if words and phrases frequently used by LLMs have increased in medical literature.
- To compare the usage trends of potentially AI-influenced terms with common academic expressions.
- To understand the timeline of these vocabulary shifts in relation to LLM development.
Main Methods:
- A systematic literature review identified 135 potentially AI-influenced terms from 15 studies.
- 84 common academic phrases were selected as control terms.
- PubMed records from 2000-2024 were analyzed, with term frequencies normalized using modified Z-scores.
Main Results:
- 103 of 135 potentially AI-influenced terms showed significant increases (modified Z-score ≥3.5) by 2024.
- Terms like "delve," "underscore," "primarily," "meticulous," and "boast" exhibited notable growth.
- Usage of these terms began rising in 2020, accelerating significantly in 2023-2024, preceding ChatGPT's release.
Conclusions:
- The increased use of certain terms in medical literature appears to be an amplification of pre-existing trends by LLMs.
- Understanding AI-driven vocabulary shifts is crucial for medical educators and researchers.
- Promoting diverse vocabulary and careful editing of AI-assisted drafts is recommended to maintain scientific writing quality.
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