Acellular Fish Skin for Deep Dermal Traumatic Wounds Management: A Case Report

Area of Science:

• Regenerative Medicine
• Biomaterials Science
• Wound Healing Research

Background:

• Extracellular matrix (ECM)-based wound dressings show potential for tissue repair.
• Bioactive components in ECM materials can accelerate healing and regeneration.
• Minimizing inflammation and promoting scar-free healing are key goals in wound management.

Purpose of the Study:

• To evaluate the efficacy of a novel wound dressing combining platelet-rich fibrin (PRF), plasma-rich growth factor (PRGF), and acellular fish skin (AFS) grafts.
• To assess healing, functional, and aesthetic outcomes in deep dermal traumatic wounds over a one-year follow-up.
• To compare the novel treatment with conventional wound care methods.

Main Methods:

• Case report involving a 34-year-old woman with deep dermal traumatic wounds.
• Treatment involved a combination of PRF gel, PRGF gel, and AFS grafts.
• Objective and subjective assessments were conducted over a 12-month period.

Main Results:

• Wounds treated with AFS demonstrated significantly faster healing rates.
• Improved skin water retention, reduced pain, and enhanced elasticity, thickness, and pigmentation were observed.
• Superior functional and aesthetic outcomes were achieved compared to conventional treatments.

Conclusions:

• The synergistic application of PRF, PRGF, and AFS grafts is a promising alternative for deep dermal wound management.
• This combination promotes accelerated healing and superior long-term outcomes.
• Decellularized fish skin grafts, combined with growth factors, offer significant advantages over split-thickness skin grafts.