Mild and Practical Method for the Synthesis of Sterically Hindered 5,5-Disubstituted Hydantoins with CO2
Naifu Hu1,2,3, Lijun Yin1, Kuoqi Yang1
1Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou 310024, China.
Abstract:
A mild and practical method was reported for the first time to prepare a variety of important sterically hindered 5,5-disubstituted hydantoins through carbonylative cyclization, which employed 1 atm of CO2 as the green carbonyl source, without using transition-metal catalysts and oxidants. This efficient process features good functional group compatibility, a broad substrate scope, facile scalability, and easy product transformation. Its utility has been demonstrated by synthesizing different medicines and bioactive compounds. This method could also be well applied to construct other types of hydantoins.
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