Efficacy of Stereotactic Body Radiotherapy in Osteosarcoma Bone Metastases

Area of Science:

• Oncology
• Radiation Oncology
• Bone Malignancies

Background:

• Osteosarcoma is the most frequent primary bone cancer in children.
• Stereotactic body radiotherapy (SBRT) is an effective ablative radiotherapy technique.
• The efficacy of SBRT for osteosarcoma bone metastases is not well-established.

Purpose of the Study:

• To evaluate the effectiveness of SBRT in managing osteosarcoma bone metastases.
• To assess treatment response and local control rates following SBRT.
• To determine the safety and toxicity profile of SBRT in this patient population.

Main Methods:

• Retrospective review of osteosarcoma patients with bone metastases treated at a single institution.
• Evaluation of treatment response using RECIST 1.1 criteria.
• Assessment of adverse events using Common Terminology Criteria for Adverse Events (CTCAE).

Main Results:

• Twelve of thirteen treated lesions (92%) demonstrated stable disease.
• Local control rates were 100% at 6 months and 87.5% at 12 months.
• Seventy-one percent of patients reported improvement in pain, with no acute grade ≥3 toxicities observed.

Conclusions:

• SBRT is a potentially effective treatment for osteosarcoma bone metastases, offering good local control and pain relief.
• SBRT exhibits a favorable acute toxicity profile in this cohort.
• Larger studies with extended follow-up are necessary to validate these preliminary findings.