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Related Experiment Video

Updated: Jan 9, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Published on: September 11, 2013

Iatrogenic Blindness Pig Model Using Hyaluronic Acid Filler Injection.

Li Tang¹, Chun-Lin Chen², Dong-Yu Cai³

¹Department of Plastic and Reconstructive Surgery, The Second People's Hospital of Foshan, Foshan, Guangdong, China.

Aesthetic Plastic Surgery

|December 8, 2025

Summary

Researchers developed a new animal model for blindness caused by hyaluronic acid (HA) injections. This model will aid in developing treatments for HA-induced ophthalmic artery occlusion (OAO) blindness.

Keywords:

Behavior Hyaluronic acid injection complication Iatrogenic blindness animal model Obstacle course Retinal artery ischemia Visual loss

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Last Updated: Jan 9, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

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Published on: September 11, 2013

Intravitreous Injection for Establishing Ocular Diseases Model

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Published on: October 1, 2007

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Published on: May 31, 2024

Area of Science:

Ophthalmology
Preclinical Research
Animal Models

Background:

Hyaluronic acid (HA) dermal filler use is increasing, leading to reports of blindness.
The mechanism of HA-induced ophthalmic artery occlusion (OAO) blindness and its treatments are poorly understood due to a lack of suitable animal models.

Purpose of the Study:

To establish a reproducible animal model of OAO-induced blindness.
To provide a preclinical platform for developing treatments for HA injection-induced blindness.

Main Methods:

HA was injected into the porcine ophthalmic artery (OA) to induce retinal ischemia.
Digital angiography, ophthalmologic exams, and behavioral tests (obstacle course) assessed vision and retinal structures.
Histological analysis (H&E staining) examined retinal damage post-embolization.

Main Results:

Angiography confirmed OA occlusion; fundus photography showed optic disk edema and a pale fundus.
Behavioral tests indicated significant visual impairment in embolized eyes.
Histology revealed retinal structural disorganization, loss of ganglion cells, and fibrosis.

Conclusions:

A reproducible porcine model for OAO-induced blindness was successfully created.
This model serves as an ideal preclinical tool for investigating treatments for HA injection-induced blindness.