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A Polyamine-Capturing Cyclodextrin Hydrogel for Periodontitis Treatment.

S Wang^1,2, W Kang^1,2, D Wang^1,2

¹Department of Periodontology/Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Journal of Dental Research

|December 9, 2025

Summary

This summary is machine-generated.

This study shows that polyamine scavenging with SCDC12 hydrogel effectively treats periodontitis. It reduces inflammation, inhibits bacterial growth, and prevents bone loss by restoring polyamine balance.

Keywords:

antibacterial biofilms inflammation nanoparticles oxidative stress spermine

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Area of Science:

Biomedical Engineering
Periodontology
Microbiology

Background:

Periodontitis involves dysregulated host-microbiota interaction and excessive inflammation.
Polyamines are implicated in periodontal inflammation and tissue destruction.

Purpose of the Study:

To investigate the therapeutic potential of polyamine scavenging for periodontitis.
To develop and evaluate a novel polyamine-capturing hydrogel (SCDC12) for periodontitis treatment.

Main Methods:

Established correlation between polyamine accumulation and periodontal inflammation using clinical samples.
Developed SCDC12 nanoparticles for polyamine capture.
Assessed SCDC12 efficacy in vitro for cellular effects and pathogen inhibition.
Evaluated SCDC12 hydrogel in a rat periodontitis model for anti-inflammatory and bone-protective effects.

Main Results:

SCDC12 nanoparticles alleviated oxidative stress, improved cell viability, and inhibited proinflammatory factors in vitro.
SCDC12 inhibited periodontal pathogen growth and biofilm formation.
SCDC12 hydrogel reduced key enzyme expression in polyamine synthesis, downregulated inflammation, and decreased alveolar bone loss in vivo.

Conclusions:

SCDC12 acts as an effective polyamine scavenger.
SCDC12 offers a novel therapeutic strategy for periodontitis by restoring polyamine homeostasis.