Scintigraphy-Positive Light-Chain Cardiac Amyloidosis
Olisa Ezegwu1, Omotola Oredipe2, Saurabh Malhotra3,4
1Division of Cardiology, Cook County Health, Chicago, Illinois.
None:
We report the cases of 3 patients with biopsy-proven light-chain cardiac amyloidosis (AL-CA) presenting with varying clinical manifestations and abnormal findings on Tc-based bone-avid scintigraphy, illustrating the diagnostic challenges of distinguishing AL-CA from transthyretin-related CA. All patients demonstrated typical electrocardiographic and echocardiographic features of CA, including low voltage and apical-sparing strain pattern. Despite abnormal scintigraphy suggestive of transthyretin-related CA, concurrent abnormal light-chain assays raised diagnostic uncertainty. Endomyocardial biopsy with mass spectrometry confirmed AL-CA in all cases. These cases emphasize the heterogeneous presentation of CA and the essential role of light-chain assays, regardless of the presence of myocardial uptake pattern on scintigraphy.
More Related Videos
Related Concept Videos
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Acute Coronary Syndrome III: Diagnostic Studies
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid Fibrils
Imaging Studies for Cardiovascular System V: CT
Cardiomyopathy IV: Restrictive Cardiomyopathy


